Looking back at the comment I probably come across as overly hash, sorry.
FWIW, one of the biggest negatives to HFOs is that while they rapidly break down in the atmosphere they end up producing trifluoroacetic acid. This stuff then rains back down, and is a polyfluoroalkyl substance (PFAS).
No worries, high quality feedback, regardless of how it comes across, is welcome. People are from many different cultures and have different tones. I comment because I know someone who knows more (or can articulate better) can chime in. I learnt something, there is another side-effect of HFOs, PFAS raining down.
definitely less than ideal