ck2 1 week ago

hmm actual paper is two years old, not sure if that website is just recycling news

* https://pmc.ncbi.nlm.nih.gov/articles/PMC11974608/

* https://link.springer.com/article/10.1007/s43440-024-00687-1

previous study from 2021

* https://www.nature.com/articles/s41598-021-87740-8

but it is fascinating

I've been trying Palmitoylethanolamide which is a studied alternative but it takes many weeks for it to start working as it has to build up in fat stores, can't say I feel anything from it yet after eight weeks

quantified 1 week ago

Which means that high-terpene cannabis can be worthwhile to get high from. Not that you necessarily want to be high all the time, but once in a while.

  • donkey_brains 1 week ago

    Ah, sadly it doesn’t work that way for me. I guess for some people it does but not for me. I can either be abstinent or constantly high.

stevenalowe 1 week ago

sigh - in mice.

  • donkey_brains 1 week ago

    This explains a lot about that mouse who got a cookie and subsequently wanted a lot of other food

  • ck2 1 week ago

    well they have to start somewhere, bringing new medical drugs to market is a decade long project

    and even worse it has to be profitable even if it works to make it to production

    I searched clinicaltrials.gov for geraniol and there is sadly nothing

    I'll have to try to email the researchers to see what they are up to next

    Maybe geraniol can be extracted from other plants that are not on any federal drug schedules, that would change everything and allow it to be marketed as a food supplement which would effectively not have any regulation at all

    ps. chatgpt says Geraniol is abundant in rose oil, palmarosa oil, citronella oil, and lemongrass oil

    which gives other legal OTC options

    it also points out they used a MASSIVE dose in the mice to get just a few hours of pain relief

    there is also a legally prescribed medication called Istradefylline that does the same thing as Geraniol

    pps. ChatGPT also says Palmitoylethanolamide is likely far more effective than Geraniol (and Palmitoylethanolamide is already legal as OTC supplement)

    • jfengel 6 days ago

      It's literally named after geraniums.